Why Torcetrapib Remains a Reference Compound in Cetp Inhibitor Research
Cholesteryl ester transfer protein plays a central role in lipid metabolism, facilitating the exchange of cholesteryl esters and triglycerides between lipoprotein particles. Genetic evidence linking lower CETP activity to higher HDL cholesterol levels gave researchers an early rationale for pharmacological inhibition – the hypothesis being that blocking CETP could shift lipid profiles in a direction … Read more